1. File Size: MP4 has a smaller size than MKV due to better compression.
2. Quality: MKV retains better quality as it supports larger file sizes.
3. Subtitles: MKV excels in offering multiple subtitle options, whereas MP4 supports subtitles but with limitations.
4. Streaming: MP4 is more streaming-friendly, while MKV may experience buffering issues.
5. Editing: MP4 is easier to edit, making it preferable for content creators.